陈诉标题(Title): Functional model of basal ganglia neural pathways for action
陈诉人(Speaker): Xin Jin (金鑫), PhD
Assistant Professor of Neurobiology and Pioneer Fund Developmental Chair
Salk Institute for Biological Studies, La Jolla, USA
所在(venue):Med-X 108 （闵行文选楼323集会室同步视频）
Topics to be discussed:
The basal ganglia has been thought to be involved in action learning and selection. When we decide to perform a voluntary action, the motor cortex sends a signal to the striatum, which is a part of basal ganglia receiving dopamine to orchestrate the sequence of motor events. Neurodegenerative diseases like Parkinson’s damage the dopamine-releasing neurons, impairing a person’s ability to execute a series of commands. Before researchers can develop targeted therapies for such diseases, they need to understand exactly what the function of dopamine is at a fundamental neurological level in normal brains. The classic model of basal ganglia suggested there are two major neural pathways, differently modulated by dopamine and working antagonistically to facilitate and inhibit movements, respectively. I'll present the recent findings we have on the physiology and function of the basal ganglia subcircuits during action sequence learning, combining in vivo recording and optogenetics in freely behaving mice. Modified rabies virus was used to further dissect the cortical control of the direct vs. indirect pathway. An updated view on the functional model of basal ganglia and its application in Parkinson's disease will be discussed.
Xin Jin received his Ph.D. in Biomedical Engineering from Shanghai Jiao Tong University, Shanghai, China in 2007. Dr. Jin conducted his postdoctoral work in the National Institutes of Health (NIH), Bethesda, USA from 2008-2011. He is currently an Assistant Professor of Neurobiology and Pioneer Fund Developmental Chair at the Salk Institute for Biological Studies, La Jolla, USA. His research interests include the molecular and circuit mechanisms of action learning and selection in the basal ganglia circuitry of health and disease. Dr. Jin and his colleagues have published their work in journals including Nature, Science, Cell, Neuron and Nature Neuroscience. He is recognized by a number of awards for academic achievements including the Benedict J. Latteri Award from NIH, Gruber International Research Award from Society of Neuroscience, and New Scholar Award from the Ellison Medical Foundation.